All You Need To Know About Antidepressants
There are seven major physical treatments for depression at present.
- Tricyclic Antidepressants (Table 1). These have until recently been by far the most widely used.
- The Monoamine Oxidase Inhibitors (MAOIs) (Table 2).
- Reversible Inhibitors of Monoamine Oxidase (RIMAs) (Table 3).
- 5-HT Reuptake Inhibitors (Table 4).
- Other Antidepressants (Table 5).
- Treatments for Bipolar Disorders or Prophylaxis of Recurrent Disorders (Table 6).
- Others (Table 7)
In the last category, a number of other treatments are marketed for or used for depression and they often work, but whether they are antidepressants in the same sense as electroconvulsive therapy (ECT), imipramine or phenelzine is a matter of dispute. The 5-HT-1a agonist, buspirone, has in addition been marketed as an antidepressant, and a further compound from this group, flesinoxan, looks as though it may also emerge as an antidepressant.
Finally, there is also ECT, the mechanism of action of which, and its use clinically will not be discussed at any length in this article. Its role when antidepressants fail to work and in cases of mania will be considered at a later stage. Read more…




